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AshwagandhaImmunity Boosting Herbal RemedyAshwagandha or Withania somnifera enhances our immunity. Enhanced Immunity safeguards us against various diseases and infections. Strengthening of immunity is done in various ways - by promoting the bodily defense mechanisms like increasing the White blood cells count. Improving Immune Function:Bodily defense mechanisms are promoted so that we are in better state to fight away various infections and to cope with the stress of other disorders. Clinical studies clearly demonstrate the immunomodulatory activity in winter cherry based on hematological and serological findings. Hemoglobin concentration, TLC or Total Leukocyte Count and WBC or White Blood Cells Count was found to be increased. Sitoindosides in WS promotes phagocytosis or the process of eating pathogens and foreign bodies by white blood cells. Ashwagandha Boosting Immunity Through Macrophages:Methanolic extract of Withania somnifera root was investigated for its immunostimulant effect on Nitric oxide (NO) production in J774 macrophages. Aswgandha caused dose dependent rise in nitric oxide production. Western blot analysis additionally confirmed that WS increased inducible NOS protein stimulation in a concentration dependent manner. It was inferred that induced NOS protein stimulation by WS might be at the level of protein transcription level. Induction of nitric oxide production in macrophages explains the immune boosting effect of WS. It might be one of the many ways how WS benefits our system. (Esposito G, Iuvone T, Life Sci. 2003 Feb. 21:72(14) 1617-25) Ashwagandha Enhancing Immunity:Immunopotentiation on oral feeding of standardized aqueous extract of Withania somnifera (Linn. Dunal, Family Solanaceae) was evaluated in laboratory animals immunized with DPT (Diphtheria, Pertussis, Tetanus) vaccine. Immunized animals were treated with Withania somnifera extract and compared with another non-treated group by exposing both groups to Bordetella pertusis strains (responsible for Diphtheria). Results showed significant increase in antibody titres as compared to untreated group. This research opens new portals for research in Immuno-Chemical industry for such immune potentiating agent. Ashwagandha Stimulating Immunity In Mice:Another study from Amala Cancer Research Center, India, suggested that administration of an extract from the powdered root of the plant Withania somnifera was found to stimulate immunological activity in Babl/c mice. Immuno-modulatory Effect Of Ashwagandha:Aggarwal et al studied immunomodulatory activity of Ashwagandha extract in experimental immune inflammation. A protective effect in cyclophosphamide-induced myelosuppression was observed in animals treated WS extract, revealing a significant increase in white blood cell counts and platelet counts. Cyclophosphamide-induced immunosuppression was counteracted by treatment with WS2, revealing significant increase in hemagglutinating antibody responses and hemolytic antibody responses towards sheep red blood cells.
Agarwal R,
Diwanay S,
Patki P,
Patwardhan B. Ashwagandha Useful In Aging & Copper Induced Conditions:Ashwagandha was investigated for copper induced lipid peroxidation and anti-oxidant enzymes in Wistar rats. Glutathione peroxidase GPx activity usually decreases in the spinal cord as the rat becomes aged. Ashwagandha treatment restored GPx activity and inhibited lipid peroxidation in dose dependent manner. Copper induced lipid peroxidation and oxidative protein modification were inhibited by Withania somnifera. These benefits are similar to those induced by Superoxide dismutase and mannitol. So it was concluded that Ashwagandha might have role in aging and copper induced physiological or pathological conditions. Gupta SK,
Dua A,
Vohra BP. Ashwagandha Helping In Chronic Fatigue Syndrome:This study reported the effect of natural and synthetic antioxidants in a mouse model of chronic fatigue syndrome. Chronic fatigue syndrome (CFS) is an illness characterized by persistent and relapsing fatigue, often accompanied by numerous symptoms involving various body systems. The etiology of CFS remains unclear; however, a number of studies have shown that oxidative stress may be involved in its pathogenesis. Co-administration of antioxidants carvedilol, melatonin, W. somnifera, quercetin or St. John's wort significantly reduced lipid peroxidation and restored the GSH levels decreased by chronic swimming in mice. Further, the treatment increased levels of SOD in the forebrain and of catalase. The findings strongly suggest that oxidative stress plays a significant role in the pathophysiology of CFS and that antioxidants could be useful in the treatment of CFS.
Singh A,
Naidu PS,
Gupta S,
Kulkarni SK.
Use Ashwagandha For:
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