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AshwagandhaPotential Of Withania somnifera In Cancer Therapy (2)Ashwagandha like some other natural botanicals shows anti-cancer potential. This is relatively safe, effective and having multiple benefits over conventional medicine. Find many benefits of Withania somnifera like enhancing the cellular immune response, stimulation of cytotoxic T Lymphocytes, effective in methylcholanthrene induced fibrosarcoma, cyclophosphamide induced urotoxicity, and as a protective agent in Leucopenia. Additionally it is found to reverse paclitaxel induced Neutropenia, to have antigranuloma activity, antioxidant activity, antiproliferative, immunosuppresive activity. All these effects are directly related to Cancer and promise its beneficial effect as a cancer herb. Ashwagandha Enhancing Cellular Immnune Response:Amala Cancer Research Center (ACRC), Thrissur, India reported another study on the effect of Withania somnifera on cellular immune response (CMI) in normal as well as tumor bearing animals. Administration of Withania extract was found to enhance the proliferation of lymphocytes, bone marrow cells and thymocytes in responses to mitogens. Natural killer cell activity (NK) was found to be enhanced significantly in both the normal and the tumour bearing group and it was found to be earlier than the control (48.92% cell lysis). Antibody dependent cellular cytotoxicity (ADCC) was found to be enhanced in the Withania treated group on the 9th day (65% cell lysis). An early Antibody dependent complement mediated cytotoxicity (ACC) was observed in the Withania treated group on day 13 (47% cell lysis). Ashwagandha Stimulating Cytotoxic T Lymphocytes:Still another study from the above mentioned center found stimulatory effect of Withania somnifera on cytotoxic T lymphocytes. These studies indicate that Withania somnifera could stimulate the generation of cytotoxic T lymphocyte and it may reduce tumour growth. Ashwagandha Supports Methylcholanthrene Induced Fibrosarcoma:Another study at ACRC suggested the effect of Withania somnifera on 20-methylcholanthrene induced fibrosarcoma. Ashwagandha Helpful In Cyclophosphamide Induced Urotoxicity:ACRC found the effect of WS extract on cyclophosphamide-induced urotoxicity. Ashwagandha Rasayanam Protecting Against Leucopenia:ACRC researchers Praveenkumar et al reported that Oral administration of Brahma Rasayana (BR) and Ashwagandha/Rasayana (AR) was found to protect mice from cyclophosphamide induced leukopenia. The results indicate the usefulness of Rasayanas in chemotherapy induced myelosuppression and leukopenia. Ashwagandha Reversing Paclitaxel Induced Neutropenia:Gupta et al noticed the reversal of paclitaxel induced neutropenia by Withania somnifera in mice. The findings of the study suggest the potential of W. somnifera as an adjuvant during cancer chemotherapy for the prevention of bone marrow depression associated with anticancer drugs. Gupta YK,
Sharma SS,
Rai K,
CK. Anti-granuloma Activity In Iraqi Ashwagandha:Researchers at Pharmacognosy & Pharmacology Dept., Scientific Research Council, Baghdad, Iraq, found anti-granuloma acitivity in Iraqi Withania somnifera. The granuloma-tissue formation inhibiting activity of various fractions of an extract of the aerial parts of Withania somnifera were established using subcutaneous cotton-pellet implantation in rats. Anti-inflammatory activity was retained in the methanolic fractions of the plant extract and was comparable to that of a 5 mg/kg dose of hydrocortisone sodium succinate. Activity was attributed to the high content of biologically active steroids in the plant, of which withaferin A is known to be a major component. al-Hindawi MK,
al-Khafaji SH,
Abdul-Nabi MH. Anti-oxidative & Anti-proliferative Activities Of Ashwagandha leaf Extract:Japanese
researchers tried to characterize various activities of leaf extract of
Ashwagandha (Lash) raised in the field and in the laboratory. We found that the
Lash from field-raised plants has a significant anti-proliferative activity in
human tumorigenic cells. However, it did not impart any protection against the
oxidative damage caused by high glucose and hydrogen peroxide to human tumor
cells suggesting that it can be used as an anti-tumor, but not as an
anti-oxidant, substance. Growth inhibition of human tumor cell lines by withanolides from Ashwagandha leaves:Michigan State University researchers isolated twelve withanolides from WS leaves. They were tested for their antiproliferative activity on NCI-H460 (Lung), HCT-116 (Colon), SF-268 (Central Nervous System; CNS and MCF-7 (Breast) human tumor cell lines. This study concluded that incorporation of withanolides in the diet may prevent or decrease the growth of tumors in human. Jayaprakasam B, Zhang Y, Seeram NP, Nair MG. Immunosuppressive activity of two plant steroidal lactones withaferin A and withanolide E:The formation of E rosette and EAC rosette by chronic lymphatic leukemic cells were inhibited by Withaferin A and Withaferin E. These experiments demonstrate a specific action of the compound on antigen recognition as well as proliferative capacity of T lymphocytes as well as B lymphocytes. Biomedicine. 1978 Jan-Feb;28(1):18-24. Ashwagandha With Chemoprotective Activity:Prakash J et al found the chemoprotective activity of Withania somnifera in experimentally induced fibrosarcoma tumors in Swiss albino mice. The mechanism of chemopreventive activity might be due to antioxidant and detoxifying properties. Prakash J,
Gupta SK,
Kochupillai V,
Singh N,
Gupta YK,
Joshi S.
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