Garcinia Cambogia

Clinical Research & Resources

Garcinia cambogia is herb of choice for weight loss by obese persons. There had been scores of clinical studies about the efficacy of this botanical. The research with Garcinia cambogia is still not conclusive. There is need for more research studies to ascertain its weight reduction role.

References Of Clinical Research Studies Of Garcinia Cambogia

  1. Lowenstein JM. Effect of (-)-hydroxycitrate on fatty acid synthesis by rat liver in vivo. J Biol Chem 1971;246:629–632.

  2. Cheema-Dhadli S, Halperin ML, Leznoff CC. Inhibition of enzymes which interact with citrate by (-)hydroxycitrate and 1,2,3,-tricarboxybenzene. Eur J Biochem. 1973;38:98–102.

  3. Sullivan AC, Triscari J, Hamilton JG et al: Effect of (-)-hydroxycitrate upon the accumulation of lipid in the rat II. Appetite. Lipids 1974; 9(2):129-134.

  4. Sullivan AC, Triscari J, Spiegel JE: Metabolic regulation as a control for lipid disorder. II. Influence of (-)-hydroxycitrate on genetically and experimentally induced hypertriglyceridemia in the rat. Am J Clin Nutr 1977;

  5. Chee J, Romsos SR, Leveille GA: Influence of (-)-hydroxycitrate on lipogenesis in chickens and rats. J Nutr 1977;107(1):112-119.

  6. Hamilton JB, Sullivan AC, Kritchevsky D: Hypolipidemeic activity of (-)-hydroxycitrate. Lipids 1977;12(1):1-9.

  7. Triscari J, Sullivan AC. Comparative effects of (-)-hydroxycitrate and (-)-allo-hydroxycitrate on acetyl CoA carboxylase and fatty acid and cholesterol synthesis in vivo. Lipids 1977;12:357–363.

  8. Greenwood MR, Cleary MP, Gruen R. Effect of (-)-hydroxycitrate on development of obesity in the Zucker obese rat. Am J Physiol. 1981; 240:E72-E78.

  9. Beynen AC, Geelen MJ: effects of insulin and glucagon on fatty acid synthesis from acetate by hepatocytes incubated with (-)-hydroxycitrate. Endokrinlgie 1982;79(2):308-10.

  10. Serudin DS, Tinggal H. 1993. Garcinia hombrioniana: A potential fruit and an industrial crop. p. 472-474. In: J. Janick and J.E. Simon (eds.), New crops. Wiley, New York.

  11. Rao TN, Sakariah KK: Lipid-lowering and anti-obesity effect or (-)-hydroxycitric acid. Nutr Res 1988;8:209-212.

  12. Sergio W: A natural food, the Malabar Tamarind, may be effective in the treatment of obesity. Med Hypotheses 1988;27(1):39-40.

  13. Brekhout TA, Havekes LM, Pearce NJ et al: The effect of HCA on the activity of the low-density-lipoprotein receptor and 3-hydroxy-3-methylglutaryl-Co-A reductase levels in the human hepatoma cell line Hep G2. Biochem J 15 1990;272(1):181-186.

  14. Sener A, Malaisse WJ: Hexose metabolism in pancreatic islets. Effect of HCA upon fatty acid synthesis and insulin release in glucose-stimulated islets. Biochimie 1991;73(10): 1287-1290.

  15. Werbach MR & Murray MT: Botanical influences on Illness: a sourcebook of clinical research. Third Line Press, Tarzana, CA; 1994.

  16. McCarty MF. Inhibition of citrate lyase may aid aerobic endurance. Medical Hypotheses. 1995;45(3):247-254.

  17. Thom E. Hydroxycitrate (HCA) in the treatment of obesity [abstract]. Int J Obes Relat Metab Disord. 1996;20(suppl 4):75.

  18. Heymsfield SB, Allison DB, Vasselli JR, Pietobelli A, Greenfield D, Nunez C. Garcinia cambogia (hydroxycitric acid) as a potential antiobesity agent: a randomized controlled trial. Journal of the American Medical Association. 1998;280(18):1596-1600.

  19. Sergio W. A natural food, the Malabar Tamarind, may be effective in the treatment of obesity. Medical Hypotheses. 1988;27(1):39-40.

  20. Kriketos AD, Thompson HR, Greene H, Hill JO. (-)-Hydroxycitric acid does not affect energy expenditure and substrate oxidation in adult males in a post-absorptive state. International Journal of Obesity Related Metabolic Disorders. 1999;23(8):867-873.

  21. Schwarz JM, Chen TW & Linfoot P: Effect of Hydroxycitrate on hepatic de novo lipogenesis, gluconeogenesis and glucose production in obese hyperinsulinemic subjects (abstract). Circulation 1999; 100(18 suppl 1):I-196-I-197.

  22. Badmaev V, Majeed M, Conte AA, et al. Garcinia cambogia for weight loss [letter]. JAMA. 1999;282:233–234.

  23. Ishihara K, Oyaizu S, Onuki K, Lim K, Fushiki T. Chronic (-)-hydroxycitrate administration spares carbohydrate utilization and promotes lipid oxidation during exercise in mice. Journal of Nutrition. 2000;130(12):2990-2995.

  24. Mattes RD, Bormann L. Effects of (-)-hydroxycitric acid on appetitive variables. Physiology and Behavior. 2000;71(1-2):87-94.

  25. van Loon LJ, van Rooijen JJ, Niesen B, Verhagen H, Saris WH, Wagenmakers AJ. Effects of acute (-)-hydroxycitrate supplementation on substrate metabolism at rest and during exercise in humans. American Journal of Clinical Nutrition. 2000;72(6):1445-1450.

  26. Jellin JM, Gregory P, Batz F, Hitchens K, et al, eds. Pharmacist's Letter/Prescriber's Letter. Natural Medicines Comprehensive Database, 3rd Edition. Stockton CA: Therapeutic Research Facility, 2000.

  27. Hasegawa N. Garcinia extract inhibits lipid droplet accumulation without affecting adipose conversion in 3T3-L1 cells. Phytotherapy Research. 2001;15(2):172-173.

  28. Koshy AS, Vijayalakshmi NR. Impact of certain flavonoids on lipid profiles--potential action of Garcinia cambogia flavonoids. Phytotherapy Research. 2001;15(5):395-400.

  29. Mahendran P, Devi CS. Effect of Garcinia cambogia extract on lipids and lipoprotein composition in dexamethasone administered rats. Indian Journal of Physiology and Pharmacology. 2001;45(3):345-350.

  30. Jena BS, Jayaprakasha GK, Singh RP, Sakariah KK. Chemistry and biochemistry of (-)-hydroxycitric acid from Garcinia. Journal of Agriculture and Food Chemistry. 2002;50(1):10-22.

  31. Westerterp-Plantenga MS, Kovacs EMR. The effect of (-)-hydroxycitrate on energy intake and satiety in overweight humans. International Journal of Obesity. 2002;26(6):870-872.

  32. Mahendran P, Sabitha KE, Devi CS. Prevention of HCl-ethanol induced gastric mucosal injury in rats by Garcinia cambogia extract and its possible mechanism of action. Indian Journal of Experimental Biology. 2002;40(1):58-62 READ MORE>>>

  33. Ohia SE, Opere CA, LeDay AM, Bagchi M, Bagchi D, Stohs SJ. Safety and mechanism of appetite suppression by a novel hydroxycitric acid extract (HCA-SX). Molecular and Cellular Biochemistry. 2002;238(1-2):89-103.

  34. Hayamizu K, Hirakawa H, Oikawa D, Nakanishi T, Takagi T, Tachibana T, Furuse M. Effect of Garcinia cambogia extract on serum leptin and insulin in mice. Fitoterapia. 2003;74(3):267-273.

  35. HealthNotes, Inc. Hydroxycitric acid. 2002. Available at: http://www.mycustompak.com/healthNotes/Supp/Hydroxycitric_Acid.htm Accessed August 15, 2003.

  36. Heber D. Herbal preparations for obesity: are they useful? Primary Care. 2003;30(2):441-463.

  37. Shara M, Ohia SE, Yasmin T, et al. Dose- and time-dependent effects of a novel (-)-hydroxycitric acid extract on body weight, hepatic and testicular lipid peroxidation, DNA fragmentation and histopathological data over a period of 90 days. Molecular and Cellular Biochemistry. 2003;254(1-2):339-346.

  38. Lenz TL, Hamilton WR. Supplemental products used for weight loss. Journal of the American Pharmacists Association (Wash DC). 2004;44(1):59-68.

  39. Mansi IA, Huang J. Rhabdomyolysis in response to weight-loss herbal medicine. American Journal of Medical Science. 2004;327(6):356-357.

  40. Pittler MH, Ernst E. Dietary supplements for body-weight reduction: a systematic review. American Journal of Clinical Nutrition. 2004;79(4):529-536.

  41. Roy S, Rink C, Khanna S, Phillips C, Bagchi D, Bagchi M, Sen CK. Body weight and abdominal fat gene expression profile in response to a novel hydroxycitric acid-based dietary supplement. Genetic Expression. 2004;11(5-6):251-262.

  42. Shara M, Ohia SE, Schmidt RE, et al. Physico-chemical properties of a novel (-)-hydroxycitric acid extract and its effect on body weight, selected organ weights, hepatic lipid peroxidation and DNA fragmentation, hematology and clinical chemistry, and histopathological changes over a period of 90 days. Molecular and Cellular Biochemistry. 2004;260(1-2):171-186.

  43. Wheeler TJ. Hydroxycitrate as a Weight-Loss Ingredient. QuackWatch. Posted November 30, 1999. Available at>>> :  Accessed August 2, 2004.

  44. Another important feedback from American Medical Association can be read at >>>



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Garcinia Cambogia - Benefit & Uses
Garcinia Cambogia - Dosage & Biochemical Composition
Garcinia Cambogia - Side Effects & Interactions
Garcinia Cambogia - Pictures & About The Plant
Garcinia Cambogia - Herbal Research


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