Clinical Research Approved Effects Of Commiphora Mukul
Guggul is one of the versatile ayurvedic herb that is
beneficial in several conditions itself and it can be fortified with other herbs
to promote some specific actions. But the scope of those formulation are within
the realm of Ayurvedic Medicine.
Find what modern research has found about Commiphora mukul gum and how it is
helpful in various conditions.
Guggul & Cholesterol Levels:
Clinical trial studies of Guggulipid now offer some conflicting results. Earlier
studies that were conducted mostly in India, offer a great evidence of its
relative safety and efficacy for lowering Cholesterol and Triglyceride and
increasing HDL cholesterol.
More than one dozen studies have affirmed its benefits while some of the later
studies in US didn't get same results. However it is widely believed that it
could be due to inappropriate dietary restrictions in those studies.
Commiphora mukul gum is greatly helpful in lowering cholesterol levels. It
should be coupled with dietary restrictions of fat intake.
This botanical gum acts on all the three components of lipid profile - HDL, LDL and
Triglycerides. There is significant lowering of cholesterol and
triglyceride levels. The ratio of HDL/LDL is also found to be favorable. This
ratio is considered as an indicator of risk of cardiovascular diseases.
antioxidants, Guggulsterones keep LDL cholesterol from oxidizing and this action
protects us against Atherosclerosis.
Another double blind clinical trial reported it to be similar to Clofibrate
drug for lipid lowering action.
(11 percent by gug.,
10 percent by clofibrate), (17 percent by gug., 22 percent by clofibrate).
Guggul Lowering LDL cholesterol Oxidation:
LDL cholesterol's oxidation is associated with Atherogenesis or development of
plaques in blood vessels. Antioxidants help by in slowing down or preventing
Atherogenesis. One study from Atherosclerosis 2004, Feb. concluded that Gug.
effectively inhibited LDL oxidation. This antioxidant action added with lipid
lowering properties make Commiphora mukul as beneficial Anti-Atherogenesis
This famous study and often quoted one against Commiphora mukul's efficacy is
published in JAMA, 2003, Aug. This study concluded that Guggulsterones in the
dose of 1000 mg and 2000 mg thrice a day, didn't appear to exert
hypcholesterolemic effects in adult patients. It could in fact raise the levels
of LDL in some patients.
After the reanalysis, it was found that this herb lowered blood pressure,
insulin levels and fasting blood sugar. It was found to exert anti-inflammatory
action and reduced the levels of C-Reactive Protein.
Guggul With Inula racemosa For Heart Health:
Inula racemosa, also known as
another traditional Ayurvedic botanical that has potential cardio-protective
benefit. In human trials, a combination of Inula racemosa and Commiphora
mukul was shown to be superior to nitroglycerin in reducing the chest
pain and dyspnea associated with angina.
Guggul & Platelets Adhesion:
Gug. is also found to reduce the stickiness of platelets and this action also
asserts lowering of risk of cardiovascular diseases. This is also helpful in
Ayurveda suggests to use Gug. in the treatment of 'Santarpana' born
disorders. This term is used for the lifestyle where in one eats a lot,
particularly high calorie diet rich in fats and carbohydrate and leads an
physically lazy life and sedentary daily routine.
Obesity as well as other "Civilization born disorders" like diabetes,
hypertension are now proved to be facilitated by this life style.
One of the Guggul's main action is to help in weight loss. It acts best when it
is coupled with dietary and exercise regimen. Remember, it is foolishness to
take herbs or other holistic treatment simply to get rid of some disease while
adopting the lifestyle that promotes that kind of disorders.
Ayurveda's first guideline for ayurvedic physicians is to remove the
factors promoting the disease from your life - food, exercise, lifestyle.
Simple, practical and effective.
Gug. helps to reduce the fat from the body so after some time your skin folds
won't look that much flabby. If its use is coupled with proper exercise, you can
dream of having a good figure.
In one double blind clinical study, Gug. was given with phosphate,
hydroxycitrate and tyrosine. This regimen was followed along with exercise. The
results showed improvement in mood and slight weight reduction in overweight
Many small studies suggested its beneficial nature in treatment of acne. In
India, ayurveda practitioners use it along with other herbs in the form like
In one small clinical trial mentioned in Journal Of Dermatology, this ayurvedic
herb is found to be equally effective as Tetracycline in the treatment of Cystic
Nodular Acne. In this trial, 500 mg of extract was given twice a day.
Degenerative joint disorders like osteoarthritis and Rheumatoid arthritis
respond well to this therapy. Commiphora mukul acts as anti-inflammatory agent
that has the potential to reduce joint pain, swelling, morning stiffness and
other related symptoms.
As in other diseases, it is not used alone in Ayurveda. Other ayurvedic herbs
are compounded with it to reach at an synergistic herbal formulation.
Trayodasanga Gug., Simhanada Gug., Yogaraja gug., Mahayogaraj gug., are
some of the commonly used formulations.
Guggul's anti-inflammatory activity is beneficial in Osteoarthritis. It was due
to Myrrhanol A which is a new triterpene found in Commiphora mukul.
In South Carolina University Of Health Sciences, USA, 2003, the use of
Commiphora mukul showed significant improvement in Osteoarthritis in both
clinical and preclinical studies. The data indicate reduction of pain and
stiffness, improved mobility and suggested it to be relatively well tolerable.
Guggul & Thyroid Function:
According to Phyto. Res. 2005, guggul is found beneficial in female mice. The herbal formulation,
Kanchanara guggulu is in use among
Ayurvedic practitioners for Hypothyroidism. This is another example of
validation of traditional herbal use by modern science.
Guggul treated group showed the parallel increased activity of anti-oxidative
enzymes - SOD (Superoxide dismutase) and CAT (Catalase). These findings for safe
and anti-peroxidative nature of this herb indicate its possible use in the
treatment of Hypothyroidism.
(Click Image) Guggul
Use Guggul For:
Obesity. Excercise & take moderate diet along with it.
For Increased Cholesterol level in blood. Prevent hardening of arteries.
For Acne with pustule containing pus pockets.
Use one vegicap twice or thrice a day with water after food. Each vegicap
has 425 mg of dried extract, standardized with standardized with 6%
Guggulsterones E & Z.